Microfluidic Cancer Diagnosis Platform.
- Reference number
- MDB10-0018
- Start and end dates
- 110501-140430
- Amount granted
- 2 100 000 SEK
- Administrative organization
- Lund University
- Research area
- Life Science Technology
Summary
This project aims to develop a microfluidic platform to streamline the identification and characterization of individual cancer cells. We aim to combine cell separation by ultrasound (acoustophoresis) with electroactive microchamber arrays that can trap and analyze single cells in parallel. If successful, the resulting technology could greatly improve cancer diagnosis in terms of its sensitivity and speed, and strengthen Swedish-Japanese academic and entrepreneurial collaborative networks. The plan is to initially use MCF-7 cells as a model for breast cancer circulating tumor cells (CTC). The Swedish side (Laurell) will develop a cell separator based on acoustophoresis. In parallell, the Japanese side (Fujii) will develop an electroactive microchamber array to trap individual MCF-7 cells. Later, the two parts will be merged into one breast cancer analysis casette. Clinical isolates of CTCs will also be tested. We expect to deliver a bedside breast cancer diagnosis tool for detailed analyses of individual CTC cells and strains.
Popular science description
Detta projekt syftar till att förena uppfinningar av den svenske forskaren Thomas Laurell med den japanske forskaren Teruo Fujis uppfinningar. Laurells metod att separera och sortera cancerceller med hjälp av ultraljud kombineras med Fujis metod för att isolera enskilda cancerceller med hjälp av ström. Målet är att bygga en komplett analyskassett som ska kunna analysera gener hos enskilda cancerceller mycket snabbt.