Low-cost high-throughput multimarker profiling
- Reference number
- SM23-0033
- Project leader
- Kubista, Mikael
- Start and end dates
- 240101-251231
- Amount granted
- 1 500 000 SEK
- Administrative organization
- Göteborg University
- Research area
- Life Sciences
Summary
Our objective is to establish robust low-cost high-throughput workflows for molecular multimarker analysis that include cell and gene therapy drug targets, and quality control software. Project builds on the workflows already available at the Institute of Biomedicine at Gothenburg University, which will be complemented with assays for siRNAs and antisense oligomers (ASOs) and quality control. The latter will be based on quality metrics that we validate and implement in a software tool. Expected results are robust workflows for molecular analysis that will make a powerful platform for basic research that can be translated to clinical studies and to a tool for compound screening in drug development. A state-of-the-art service platform will be established at the University. Some of the solutions developed will be possible to protect and commercialize through licensing, while the quality control analysis will go into software products.
Popular science description
Vi utvecklar plattformar för att kostnadseffektivt och storskaligt mäta stort antal biomarkörer, däribland den nya typen av läkemedel kallade ATMP, i ett mycket stort antal prover samtidigt, med säkerstäld kvalitet. Dessa nya effektiva screeningsplattformar är oerhört betydelsefulla inom grundläggande forskning, men även för rutindiagnostik och läkemedelsutveckling