Biocompatible materials for coating medical implants
- Reference number
- UKR22-0040
- Project leader
- Nosenko, Valentyna
- Start and end dates
- 220501-241231
- Amount granted
- 2 000 000 SEK
- Administrative organization
- Linköping University
- Research area
- Materials Science and Technology
Summary
The ultimate aim of the implants coatings study is the improvement of medical implants functioning via optimization of biocompatible coating that prevents the rejection of an implant by the surrounding tissues. The goal of the present project is to analyze the influence of source materials properties (chemical properties, granulometric composition) as well as fabrication parameters on the composition and properties of biocompatible coatings for medical implants. The objects studied are: the coatings – calcium phosphate- and apatite-based coatings; the implants – metallic medical implants; fabrication method - detonation spraying. Since the initial material is exposed to high temperatures during the deposition process, it is planned to study in details the thermally-induced changes of structure and properties of calcium phosphates and the related composites of different chemical and granulometric compositions. Based on the obtained data the recommendations for production of biocompatible coatings with specified characteristics will be advanced.
Popular science description
Metallic implants are widely used in world medical practice, including surgery, traumatology and dentistry, due to their excellent mechanical properties (high stability, mechanical strength, relatively inexpensive manufacturing). However, their contact with living tissues causes a number of undesirable effects (e.g. complications during or after surgery, such as infection, inflammation, and pain; rejection of implants by the host body due to implant-induced coagulation and allergic foreign body response). To avoid these complications, metallic implants are coated with the materials ensuring osseointegration with living tissues. For these coatings the compounds and composites based on calcium phosphates, in particular calcium apatite, are most widely used. The reason for this choice is the similarity of their composition and characteristics to the corresponding mineralized tissues of living organisms. However, on the way from the original calcium phosphate (or composite based on it) to an effective medical implant there are many tasks, in particular, the establishing of relationships between the characteristics of the source and final deposited materials, finding the ways to control quality at different stages of the fabrication process. The ultimate aim of this research field is to improve medical implants functioning via optimization of biocompatible coating that prevents the rejection of an implant by the surrounding tissues. The goals of the present project is to analyze the influence of source materials properties (chemical properties, granulometric composition) as well as fabrication parameters on the composition and properties of biocompatible coatings for medical implants. The objects studied are: the coatings – calcium phosphate- and apatite-based coatings; the implants – metallic medical implants; fabrication method - detonation spraying. Since the initial material is exposed to high temperatures during the deposition process, it is planned to study in details the thermally-induced changes of structure and properties of calcium phosphates and the related composites of different chemical and granulometric compositions. Based on the obtained data the recommendations for production of biocompatible coatings with specified characteristics will be advanced.