Targeting Adipose Senescence for Treatment of Diabetes
- Diarienummer
- ID19-0009
- Projektledare
- Boucher, Jeremie
- Start- och slutdatum
- 200101-241231
- Beviljat belopp
- 2 500 000 kr
- Förvaltande organisation
- Göteborg University
- Forskningsområde
- Livsvetenskaperna
Summary
I do not speak Swedish fluently
Populärvetenskaplig beskrivning
Aging of cells or cellular senescence is a major factor behind tissue and organ function in the elderly. Impaired adipose tissue capacity to store lipids is closely associated with diabetes and cardiovascular diseases, at least in part due to fat accumulating in non-fat tissues causing detrimental effects. Our preliminary results indicate that cellular aging of adipose tissue cells plays a major role in this process, by secreting factors which promote inflammation and insulin resistance and impairing adipose tissue expansion. We propose to 1) characterize aging markers in human adipose tissue in several large human patient cohorts and investigate their relation to disease. We will perform gene expression analyses from adipose tissue from individuals with a wide range in body body weight and adipose tissue morphology, with corresponding information on established diabetes, family history of diabetes and data on lipids, inflammation, insulin sensitivity, and cardiovascular disease 2) identify senescence-associated secreted factors from adipose tissue, and their associations with diseases. We will measure secretion from adipose tissue of key factors identified, and their levels in blood from healthy non-obese, obese, and diabetic subjects, with or without cardiovascular complications 3) determine the effect of the senescence-associated factors on adipose tissue cell function, lipid transport and overall metabolism. Overall, we anticipate that this project will be able to identify the key drivers of adipose tissue aging, and identify factors which could be novel therapeutic targets for the treatment of cardiometabolic diseases.